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Full text of "Pathogenic Bacteria"

IMMUNITY AND SUSCEPTIBILITY.          77

encased produce an inflammatory transndate which may
have properties very different from those of the normal
juices.

How much of the immunity which animals enjoy de-
pends upon the antibactericidal action of their body-
juices must remain an open question. In some cases the
germicidal action of the blood seems to be unquestion-
able. Buchner has shown that the blood-serum of ani-
mals only possesses this germicidal power when freshly
drawn, and that exposure of the serum to sunlight, its
mixture with the serum from another species of animal,
its mixture with distilled water or with dissolved cor-
puscles, and heating" it to 55 C., check the bactericidal
power. Buchner also points out that the bactericidal
and globulicidal actions of the blood are simultaneously
extinguished. Meltzer and Morris1 found that lymph
taken from the thoracic duct of the dog possessed marked
bactericidal powers upon the typhoid bacillus.

The experiments of Pfeiffer seem to add additional
support to the humoral theory of immunity. He found
that when guinea-pigs were given experimental choleraic
peritonitis, they could be saved from death from the affec-
tion by intraperitoneal injection of serum from an
immunized animal. He also showed that when the cul-
ture of cholera, or a culture <?f typhoid bacilli, was in-
jected into the peritoneum of a guinea-pig, the multipli-
cation of the bacteria was rapid. If, however, a lew
drops of the immunized serum were introduced, a marked
effect was observed, for the serum seemed to exert a
germicidal effect upon the bacteria, and transform them
from living entities into inanimate little granular masses.

Hankin is of the opinion that; the gennieidal sub-
stances of the blood-serum are derived from the eosinophile
cells, and resides in the matter forming the eosin-granules.

Lowit,2 in investigating the bactericidal power of the

1  Journal of Rxpcrimcntal Medicine, vol. ii,, No. 6, p. 701, Nov., 1807.

2  Bietrage zur Pathol. Anatomic mitl  zur AlJ^cm. Pathologic, Bd. xxil., H,
i, P- 173-